The science

Every milligram, fully disclosed.

No proprietary blends. No marketing-only doses. This page lists every active ingredient in every PawVolt formula — with source, mechanism, and the evidence behind the dose.

24
Active ingredients
100%
Dose disclosure
3rd
Party lab tested
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Formula 1 of 4

Joint & Mobility

For stiffness, slowing down, and aging joints. Glucosamine + Chondroitin + MSM at clinical doses, plus Turmeric and Omega-3 for the inflammatory side.

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Glucosamine HCl

500 mg / serving
SourceShellfish (sustainably sourced)
MechanismAmino sugar precursor for cartilage proteoglycan synthesis; stimulates chondrocyte repair.
EvidenceMultiple veterinary RCTs show meaningful lameness reduction in osteoarthritic dogs at 500 mg/day for medium breeds over 6-8 weeks.

Chondroitin Sulfate

400 mg / serving
SourceBovine cartilage (NA + EU)
MechanismInhibits cartilage-degrading enzymes (MMPs, elastase), helps retain synovial fluid viscosity.
EvidenceSynergistic with glucosamine in joint health trials; ratio 5:4 used in this formula matches the standard clinical pairing.

MSM (Methylsulfonylmethane)

250 mg / serving
SourceNaturally-derived sulfur compound (USA-produced)
MechanismProvides bioavailable sulfur for collagen + keratin synthesis; reduces oxidative stress in joint tissue.
EvidenceDemonstrated anti-inflammatory effects in canine osteoarthritis studies; well-tolerated up to 1g/kg.

Turmeric (Curcumin 95%)

100 mg / serving
SourceIndia, organic Curcuma longa root
MechanismInhibits NF-κB and COX-2 inflammatory pathways; complementary to MSM.
EvidenceBest-studied of plant anti-inflammatories. Bioavailability enhanced when paired with the omega-3 oil in this same formula.

Omega-3 Fish Oil (EPA + DHA)

300 mg / serving
SourceWild-caught small fish, MSC-certified
MechanismEPA reduces production of inflammatory eicosanoids; DHA supports cartilage cell membrane integrity.
EvidenceVeterinary nutrition consensus supports omega-3s for joint comfort and mobility in mature dogs.

Vitamin C & E (antioxidant pair)

50 mg / serving
SourceAscorbic acid + d-alpha tocopherol
MechanismCofactor for collagen synthesis (C); protects cellular membranes from oxidative damage (E).
EvidenceStandard supportive nutrients in canine joint nutrition. Synergistic with the omega-3 above.
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Formula 2 of 4

Gut Health

For loose stools, gas, and slow digestion. Spore-forming probiotic + prebiotic + digestive enzymes that survive the acid bath and actually reach the gut.

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Bacillus Coagulans (spore-forming probiotic)

5 Billion CFU / serving
SourceGanedenBC30® strain
MechanismSpore-form survives stomach acid intact; germinates in the small intestine and produces lactic acid + bacteriocins that crowd out pathogens.
EvidenceHeat-stable and shelf-stable — does not require refrigeration. Higher gut delivery vs lactobacillus alone.

Lactobacillus Acidophilus

2 Billion CFU / serving
SourceStandard dairy-fermented strain (encapsulated)
MechanismRestores small-intestine flora balance; produces lactic acid that lowers gut pH to discourage pathogens.
EvidenceMost-studied probiotic species across mammalian gut research.

Digestive Enzyme Blend (Protease + Lipase + Amylase)

100 mg blend / serving
SourceMicrobial fermentation, plant-based
MechanismBreaks down protein, fat, and carbs that aging or stressed digestive systems struggle to process.
EvidenceSupports nutrient absorption when a dog's pancreatic output declines with age or after stress.

Inulin (Prebiotic Fiber)

250 mg / serving
SourceChicory root
MechanismSelective fuel for beneficial gut bacteria; fermented into short-chain fatty acids that nourish colon cells.
EvidenceSymbiotic pairing — probiotics + prebiotic — outperforms either alone in microbiome restoration.

Pumpkin Powder

150 mg / serving
SourceWhole pumpkin flesh, dehydrated
MechanismSoluble fiber + pectin to firm stool consistency and soothe the GI tract.
EvidenceLong-standing veterinary recommendation for transient digestive upset.

MCT Oil (Medium-Chain Triglycerides)

200 mg / serving
SourceCoconut-derived C8/C10
MechanismDirect fuel for enterocytes (gut wall cells), supporting barrier integrity.
EvidenceBypasses standard fat-digestion pathway — easier on dogs with pancreatic or absorption issues.
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Formula 3 of 4

Skin & Coat

For itching, shedding, and dull coats. Omega-3 fatty acids and bioavailable minerals that rebuild the skin barrier from the inside.

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Omega-3 EPA + DHA

500 mg / serving
SourceWild salmon + sardine, MSC-certified
MechanismAnti-inflammatory eicosanoids; incorporated into skin cell membranes to reduce itch and reactivity.
EvidenceStrongest single-ingredient evidence base for canine skin and coat health.

Biotin (Vitamin B7)

5 mg / serving
SourcePure crystalline biotin
MechanismCofactor for keratin synthesis — the structural protein in fur and hair shafts.
EvidenceBiotin deficiency well-documented as a cause of poor coat quality; supplementation reverses thinning.

Zinc Methionine

15 mg / serving
SourceChelated mineral (highest bioavailability form)
MechanismEssential for skin cell regeneration and barrier function; supports immune response in skin tissue.
EvidenceMethionine-chelated form is 4x more bioavailable than zinc oxide/sulfate.

Vitamin E (d-alpha tocopherol)

25 IU / serving
SourceNatural-source tocopherol
MechanismLipid-phase antioxidant — protects skin cell membranes from peroxidation.
EvidenceSynergistic with the omega-3s in this formula (protects the fish oil from oxidation in vivo).

Evening Primrose Oil (GLA)

200 mg / serving
SourceCold-pressed Oenothera biennis seed
MechanismGamma-linolenic acid (GLA), an omega-6 dogs poorly synthesize themselves; calms skin inflammation.
EvidenceUsed clinically in canine atopic dermatitis with measurable itch reduction.

Vitamin A (Beta-Carotene)

1,500 IU / serving
SourcePlant-derived beta-carotene
MechanismSupports epithelial cell turnover; converted to active retinoids as needed.
EvidenceBeta-carotene form is safer than direct vitamin A — body converts only what it needs.
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Formula 4 of 4

Calming & Stress

For anxiety, reactivity, and storm fear. Adaptogens and amino acids that calm the nervous system without sedating.

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Ashwagandha KSM-66®

300 mg / serving
SourceStandardized full-spectrum root extract
MechanismAdaptogen — modulates HPA axis and lowers serum cortisol; does not sedate.
EvidenceMost-studied ashwagandha extract in the world; KSM-66 specifically validated in 20+ human RCTs and emerging canine trials.

L-Theanine (Suntheanine®)

100 mg / serving
SourcePharmaceutical-grade L-isomer
MechanismCrosses blood-brain barrier; increases alpha-wave EEG activity (calm focus state).
EvidenceVeterinary use in storm phobia and travel anxiety; clinical effect typically within 30-60 minutes.

Chamomile Extract

100 mg / serving
SourceMatricaria recutita flower
MechanismApigenin binds GABA-A receptors with anxiolytic but not sedative effect.
EvidenceLong-standing use in herbal veterinary practice for mild anxiety.

Valerian Root

75 mg / serving
SourceValeriana officinalis
MechanismInhibits GABA breakdown; promotes calm and supports natural sleep cycles.
EvidenceStandard herbal calming agent in companion-animal nutrition.

Magnesium Glycinate

50 mg / serving
SourceChelated mineral (highest bioavailability)
MechanismNMDA receptor modulation; reduces neuronal excitability.
EvidenceGlycinate form gentler on GI than oxide; better absorption.

GABA (Gamma-Aminobutyric Acid)

100 mg / serving
SourceFermentation-derived
MechanismDirect supply of the brain's primary inhibitory neurotransmitter.
EvidenceSynergistic with chamomile + valerian for compound calming effect without drowsiness.
Sourcing transparency

Where every gram comes from.

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Made in Canada

Made in Canada in a cGMP facility and third-party tested for purity and potency — every batch.

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Third-party lab tested

Each lot tested for identity, potency, heavy metals, and microbial limits. Certificates of Analysis available on request.

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Full label disclosure

Every active ingredient with its exact dose on the front of the label. No "proprietary blends," no hiding behind generic terms.

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Clinically meaningful doses

Actives are dosed at levels supported by research — not sprinkled in at trace amounts just to list them on the label.

Our standard
Our formulation philosophy

"We pick every ingredient because the evidence is there — and dose it where the research says it works. Not because it polls well on Instagram."

— The PawVolt formulation team

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